yeah, very good question. I've been thinking about this myself as well since I am working on a visual tool. Since 25% of users (I heard this number last week in a seminar about this topic, but can't find online docs to support this) of regular websites have some sort of (temporarily) accessiblity issues, this deserves attention. I can imagine that it should be possible to "tab" through a visual flow following the connections somehow. Keyboard access in general is needed offcourse. And also simply using color combinations with a good enough contrast ratio. But I wonder if a "nodes and wire" visual-model helps people who are blind, even if a screenreader would work properly with such interface. Would this give you a proper mental model of the visual flow? Would a different kind of flow work better? In my day job I have to take accessibility into account (the website/webapp I currently work on has users who are blind for example). But for my own flow-based-programming project I don't take this into account yet (I simply dont have the time and its a project without users anyway currently), but in the future I probablly will take it into account.